Web
- Ensure you have installed the mysql extension of your PHP version (Ex: php7.2-mysql)
- Ensure pdo_mysqlmodule is loaded, checkphpinfo()for this
Plugin
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Please make sure dbi.mysql.ext.so(dbi.mysql.ext.dllon Windows) extension exists and check if it is loaded via sm exts list
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Make sure the extension is executable via chmod u+x dbi.mysql.ext.so
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Install zlib(Requires SSH Access)- 
32-Bit Debian/Ubuntu: apt-get install zlib1g
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64-Bit Debian/Ubuntu: apt-get install lib32z1
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32/64-Bit Fedora: yum install zlib.i686
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32/64-Bit Mandriva: urpmi zlib1
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32-Bit SUSE: zypper install libz1
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64-Bit SUSE: zypper install libz1-32bit
 
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If all of the above does not work, use ldd -d -r dbi.mysql.ext.soto look for missing dependencies, and use Google to look them up